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Gautrot

Academic Expert Directory - Profile Details

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Dr Julien Gautrot

Bio-interfaces, the interfaces between proteins, cells or tissues and inert materials, are fascinating systems that play key roles in biological and biomedical applications. Research in the Gautrot lab focuses on the design of novel biomaterials and methodologies that allow the study of bio-interfaces and their control for applications in cell-based assays, bio-sensors and regenerative medicine. Our work in the field of biomaterials design is inspired by Nature’s strategies to generate complexity and control function and properties. In particular, we are interested in novel synthetic tools and methodologies allowing the use of Nature’s own building blocks, peptide sequences, to confer mechanical, chemical and biological properties to biomaterials. This approach, well suited for design, is appealing as it makes use of the inherent biological “wiring” that has evolved to control cell and tissue homeostasis: peptide sequences and proteins are the key components that shape biological tissues. In addition, we develop new micro- and nano-patterning techniques to recreate the geometric and hierarchical complexity encountered in cells and tissues (e.g. positioning of organelles, generation of cell polarity and mimicking of tissue architecture and morphogenesis). Key questions that these tools will allow us to address are: how do biological, mechanical and chemical properties of bio-materials (whether synthetic or of natural origin) cross-talk to control cell behaviour and in particular stem cell fate decision? How do cells remodel such materials and how does this impact on cell behaviour and tissue formation? Finally, what is the minimum set of rules or properties required to achieve a desired cell or tissue function?

Lecturer in Biomaterials
Queen Mary University of London
j.gautrot@qmul.ac.uk

Name of Institution:
Queen Mary University of London
Department :
School of Engineering and Materials Sciences
Address :
Mile End Road
City:
London
Postal Code :
E1 4NS
Location of Academic Expert:
United Kingdom
Current Position:
Lecturer in Biomaterials
Previous Positions:
Postdoctoral Research, University of Cambridge
Academic, Educational , Professional Qualifications:
PhD (Chemistry)

Areas of Expertise:
- Technology

Other (Areas of Expertise): Biomaterials Tissue Engineering

Types of Service:
- Research/peer review
- Training/education

Recent/Key Publications:
17. Tan, K.Y.; Lin, H.; Ramstedt, M.; Watt, F.M.; Huck, W.T.S.; Gautrot, J.E. “Decoupling geometrical and chemical cues directing epidermal stem cell fate on polymer brush-based cell micro-patterns”. Integr. Biol. 2013, 5, 899-910. 16. Rzhepishevska, O.; Hakobyan, S.; Ruhal, R,; Gautrot, J.E.; Barberoc, D.; Ramstedt, M. “The surface charge of anti-bacterial coatings alters motility and biofilm architecture” Biomater. Sci. 2013, 1, 589-602. 15. Trappmann, B.; Gautrot, J.E.; Connelly, J; Strange, D.G.T.; Li, Y.; Oyen, M.; Cohen Stuart, M.A.; Boehm, H.; Li, B.; Vogel, V.; Spatz, J.P.; Watt, F.M.; Huck, W.T.S. “Extracellular matrix tethering regulates stem cell fate”. Nat. Mater. 2012, 11, 642-649. 14. Gautrot, J.E.; Wang, C.; Liu, X.; Goldie, S.; Trappmann, B.; Huck, W.T.S.; Watt, F.M. “Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis”. Biomaterials 2012, 33, 5221-5229. 13. Connelly, J; Mishra, A.; Gautrot, J.E.; Watt, F.M. “Shape-induced terminal differentiation of human epidermal stem cells requires p38 and is regulated by histone acetylation”. PLoS One 2011, 6, e27259. 12. Rodriguez-Emmenegger, C.; Brynda, E.; Riedel, T.; Houska, M.; Subr, V.; Alles, A.B.; Hasan, E.; Gautrot, J.E.; Huck, W.T.S. “Polymer brushes showing non-fouling in blood plasma challenge the currently accepted design of protein resistant surfaces”. Macromol. Rapid Commun. 2011, 32, 952-957. 11. Tan, K.Y.; Gautrot, J.E.; Huck, W.T.S. “Island brushes to control adhesion of water in oil droplets on planar surfaces”. Soft Matter 2011, 7, 7013-7020. 10. Strandman, S.; Gautrot, J.E.; Zhu, X.X. “Recent advances in entropy-driven ring-opening polymerizations”. Polymer Chemistry 2011, 2, 791-799. 9. Tan, K.Y.; Gautrot, J.E.; Huck, W.T.S. “Formation of Pickering emulsions using ion-specific responsive colloids”. Langmuir 2011, 27, 1251-1259. 8. Connelly, J; Gautrot, J.E.; Trappmann, B.; Tan, D.W.M.; Donati, G.; Huck, W.T.S.; Watt, F.M. “Actin and SRF transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions”. Nat. Cell Biol. 2010, 12, 711-U177. 7. Gautrot, J.E.; Trappmann, B.; Oceguera-Yanez, F.; Connelly, J.; He, X.;Watt, F.M.; Huck, W.T.S. “Exploiting the superior protein resistance of polymer brushes to control single cell adhesion and polarisation at the micron scale”. Biomaterials 2010, 31, 5030-5041. 6. Gautrot, J.E.; Huck, W.T.S.; Welch, M.; Ramstedt, M. “Protein-resistant NTA-functionalized polymer brushes for selective and stable immobilization of histidine-tagged proteins”. Appl. Mater. Interfaces 2010, 2, 193-202. 5. Therien-Aubin, H.; Gautrot, J.E.; Zhu, X.X. “Shape memory properties of main chain bile acids polymers”. Polymer 2010, 51, 22-25. 4. Trmcic-Cvitas, J.; Hasan, E.; Ramstedt, M; Li, X.; Cooper, M.; Abel, C.; Huck, W.T.S.; Gautrot, J.E. “Bio-functionalized protein resistant oligo(ethylene glycol)-derived polymer brushes as selective immobilization and sensing platforms”. Biomacromolecules 2009, 10, 2885-2894. 3. Gautrot, J.E.; Zhu, X.X. “Shape memory materials based on naturally occurring bile-acids”. Macromolecules 2009, 42, 7324-7331. 2. Gautrot, J.E.; Hodge, P.; Helliwell, M; Raftery, J.; Cupertino, D. “Synthesis of electron-accepting polymers containing phenanthra-9,10-quinone units” J. Mat. Chem. 2009, 19, 4148-4156. 1. Gautrot, J.E.; Zhu, X.X. “Macrocyclic bile acids: from molecular recognition to degradable bio-material building blocks” J. Mat. Chem. 2009, 19, 5705-5716.

Link to relevant website (1): Personal webpage
Link to relevant website (2): SEMS webpage
Working languages: English French